Wednesday 11th of December


08:30-09:30: registration + welcome coffee


Inflammation and immunity: at the crossroad of ageing pathway

09:30-10:20: David Dombrowicz (UMR1011, Institut Pasteur de Lille, France)

“Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR”


10:20-10:50: Flavie Coquel (Univ. Montpellier, France / EPFL, Switzerland)

“A new link between DNA replication stress and the production of Type I IFNs”


10:50-11:10: coffee break


11:10-11:40:  Andrea Ablasser (EPFL, Switzerland)

 Title tbd

11:40 -12:10: 2 short oral presentations

  • Clément Crochemore (Institut Pasteur, Paris, France)

"A defective pathway in progeroid Cockayne syndrome reveals a novel and early determinant of replicative senescence in normal cells"


  • Alicia Mayeuf Louchart (UMR1011, Institut Pasteur Lille, France)

"Glycogen dynamics drives lipid droplet biogenesis during brown adipocyte differentiation"


12:10-14:00:  Lunch + poster viewing


14:00-14:30: Jean-Pierre Hugot (AP-HP, Paris, France)

"Is Crohn disease the price to pay today for having survived to the black death?”

14:30-15:00: Léa Rémy-Tourneur (Univ. Paris Descartes, France)

"FADD protein regulation at the crossroads between cancer and inflammation"


15:00-15:30: 2 short oral presentations

  • Emmanuelle Born (U955, Hopital Henri Mondor, Ap-HP, Créteil, France)

"Senescent cells protect against pulmonary hypertension development in mice"


  • Olivier Pluquet (UMR8161, Institut Pasteur de Lille, France)

 "The Activating Transcription Factor 6α (ATF6α) signaling of the UPR controls features of the senescent phenotype in human fibroblasts"


15:30- 16:00: coffee break


16:00 – 16:50: Victor Appay (Sorbonne, Salpetriere, Paris)

"Aging of lymphocytes through time and differentiation"

17:00-18:30: poster viewing + face-to-face meetings with the speakers (10min/person)


18:30-19:30: cocktail with all attendees




Thursday, 12th of December




09:00-09:30: Frank Lafont (CIIL, Institut Pasteur de Lille, France)

“Autophagy-mediated mechanisms and membrane biophysics during host-pathogen interactions”


09:30- 10:00: Patricia Boya (Centro de Investigaciones Biologicas, CIB-CSIC, Madrid)

“Autophagy in neurons: development degeneration and aging”


10:00-10:30Franck Oury (Necker Hospital, Paris, France )

“Role of autophagy in mediating the effects of systemic factors on cognitive fitness and brain plasticity”


10:30-11:00: coffee break


Cell autonomous and cell non-autonomous homeostasis


11:00-11:30: Felipe Cabral (Univ of Chile)

"XBP1s is a modulator of mammalian health span"


11:30-12:00: Mario Pende (Paris, Descartes University, France)

“Control of growth and senescence by nutrient sensing and the mTOR/S6 kinase pathway”


12:00-12:30: 2 short oral presentations

  •  Suchira Gallage (Univ. Heidelberg, Germany)

"Platelet GPlbα is a mediator interventional target for NASH and subsequent liver cancer"


  • Erwan Lambert (U1167, Institut Pasteur de Lille, France)

"Characterization of the neurotoxicity in the Alzheimer Disease risk factor BIN1 in drosophila"


12:30-14:00:  Lunch + poster viewing


Therapeutic strategies against ageing-related diseases


14:00-14:30: Dean Hum (Genfit, Lille, France)

 Title tbd


14:30-15:00: Mathias Heikenwälder (Univ. Heidelberg, Germany)

“On the role of innate and adaptive immune cells in NASH and liver cancer development”

15:00-15:30: Gavin Richardson (Univ. Newcastle, UK)

“Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction”


15:30-16:00: Bernard Thorens (Switzerland)

 "Defence against hypoglycemia through brain neuronal circuits"


16:00: concluding remarks