Wednesday 11th of December
08:30-09:30: registration + welcome coffee
Inflammation and immunity: at the crossroad of ageing pathway
09:30-10:20: David Dombrowicz (UMR1011, Institut Pasteur de Lille, France)
“Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR”
10:20-10:50: Flavie Coquel (Univ. Montpellier, France / EPFL, Switzerland)
“A new link between DNA replication stress and the production of Type I IFNs”
10:50-11:10: coffee break
11:10-11:40: Andrea Ablasser (EPFL, Switzerland)
11:40 -12:10: 2 short oral presentations
- Clément Crochemore (Institut Pasteur, Paris, France)
"A defective pathway in progeroid Cockayne syndrome reveals a novel and early determinant of replicative senescence in normal cells"
- Alicia Mayeuf Louchart (UMR1011, Institut Pasteur Lille, France)
"Glycogen dynamics drives lipid droplet biogenesis during brown adipocyte differentiation"
12:10-14:00: Lunch + poster viewing
14:00-14:30: Jean-Pierre Hugot (AP-HP, Paris, France)
"Is Crohn disease the price to pay today for having survived to the black death?”
14:30-15:00: Léa Rémy-Tourneur (Univ. Paris Descartes, France)
"FADD protein regulation at the crossroads between cancer and inflammation"
15:00-15:30: 2 short oral presentations
- Emmanuelle Born (U955, Hopital Henri Mondor, Ap-HP, Créteil, France)
"Senescent cells protect against pulmonary hypertension development in mice"
- Olivier Pluquet (UMR8161, Institut Pasteur de Lille, France)
"The Activating Transcription Factor 6α (ATF6α) signaling of the UPR controls features of the senescent phenotype in human fibroblasts"
15:30- 16:00: coffee break
16:00 – 16:50: Victor Appay (Sorbonne, Salpetriere, Paris)
"Aging of lymphocytes through time and differentiation"
17:00-18:30: poster viewing + face-to-face meetings with the speakers (10min/person)
18:30-19:30: cocktail with all attendees
Thursday, 12th of December
09:00-09:30: Frank Lafont (CIIL, Institut Pasteur de Lille, France)
“Autophagy-mediated mechanisms and membrane biophysics during host-pathogen interactions”
09:30- 10:00: Patricia Boya (Centro de Investigaciones Biologicas, CIB-CSIC, Madrid)
“Autophagy in neurons: development degeneration and aging”
10:00-10:30: Franck Oury (Necker Hospital, Paris, France )
“Role of autophagy in mediating the effects of systemic factors on cognitive fitness and brain plasticity”
10:30-11:00: coffee break
Cell autonomous and cell non-autonomous homeostasis
11:00-11:30: Felipe Cabral (Univ of Chile)
"XBP1s is a modulator of mammalian health span"
11:30-12:00: Mario Pende (Paris, Descartes University, France)
“Control of growth and senescence by nutrient sensing and the mTOR/S6 kinase pathway”
12:00-12:30: 2 short oral presentations
- Suchira Gallage (Univ. Heidelberg, Germany)
"Platelet GPlbα is a mediator interventional target for NASH and subsequent liver cancer"
- Erwan Lambert (U1167, Institut Pasteur de Lille, France)
"Characterization of the neurotoxicity in the Alzheimer Disease risk factor BIN1 in drosophila"
12:30-14:00: Lunch + poster viewing
Therapeutic strategies against ageing-related diseases
14:00-14:30: Dean Hum (Genfit, Lille, France)
14:30-15:00: Mathias Heikenwälder (Univ. Heidelberg, Germany)
“On the role of innate and adaptive immune cells in NASH and liver cancer development”
15:00-15:30: Gavin Richardson (Univ. Newcastle, UK)
“Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction”
15:30-16:00: Bernard Thorens (Switzerland)
"Defence against hypoglycemia through brain neuronal circuits"
16:00: concluding remarks