Wednesday 11th of December
08:30-09:30: registration + welcome coffee
09:30-09:40: Welcome introduction by Benoit Deprez, Scientifi director of Institut Pasteur de Lille
Inflammation and immunity: at the crossroad of ageing pathway
09:40-10:30: Keynote lecture : David Dombrowicz (UMR1011, Institut Pasteur de Lille, France)
“Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR”
10:30-10:45: Olivier Pluquet (UMR8161, Institut Pasteur de Lille, France)
"The Activating Transcription Factor 6α (ATF6α) signaling of the UPR controls features of the senescent phenotype in human fibroblasts"
10:45-11:15: coffee break
11:15-11:45: Bernard Thorens (Switzerland)
"Defence against hypoglycemia through brain neuronal circuits"
11:45 -12:00: Clément Crochemore (Institut Pasteur, Paris, France)
"A defective pathway in progeroid Cockayne syndrome reveals a novel and early determinant of replicative senescence in normal cells"
12:00 - 12:15: Alicia Mayeuf Louchart (UMR1011, Institut Pasteur Lille, France)
"Glycogen dynamics drives lipid droplet biogenesis during brown adipocyte differentiation"
12:15-14:00: Lunch + poster viewing
14:00-14:30: Jean-Pierre Hugot (AP-HP, Paris, France)
"Is Crohn disease the price to pay today for having survived to the black death?”
14:30-14:45: Emmanuelle Born (U955, Hopital Henri Mondor, Ap-HP, Créteil, France)
"Senescent cells protect against pulmonary hypertension development in mice"
14:45 - 15:00: Erwan Lambert (U1167, Institut Pasteur de Lille, France)
"Characterization of the neurotoxicity in the Alzheimer Disease risk factor BIN1 in drosophila"
15:00- 15:30: coffee break
15:30 – 16:00: Victor Appay (Sorbonne, Salpetriere, Paris)
"Aging of lymphocytes through time and differentiation"
16:00 – 16:15 : Dimitra Gkika (Inserm U1003, University Lille)
"Hormonal changes : the TRP channel pathways"
16:30-17:30: poster viewing
17:30-18:30: cocktail with all attendees
Thursday, 12th of December
09:00-09:30: Frank Lafont (CIIL, Institut Pasteur de Lille, France)
“Autophagy-mediated mechanisms and membrane biophysics during host-pathogen interactions”
09:30- 10:00: Franck Oury (Necker Hospital, Paris, France )
“Role of autophagy in mediating the effects of systemic factors on cognitive fitness and brain plasticity”
10:00-10:15: Suchira Gallage (Univ. Heidelberg, Germany)
"Platelet GPlbα is a mediator interventional target for NASH and subsequent liver cancer"
10:15-10:40: coffee break
Cell autonomous and cell non-autonomous homeostasis
10:40-11:10: Felipe Cabral (Univ of Chile)
"XBP1s is a modulator of mammalian health span"
11:10-11:40: Mario Pende (Paris, Descartes University, France)
“Control of growth and senescence by nutrient sensing and the mTOR/S6 kinase pathway”
11:40-12:10: Miroslav Radman (MedILS, Split, Croatia)
"Molecular and cellular aspects of aging and age-related diseases"
12:10-13:30: Lunch + poster viewing
Therapeutic strategies against ageing-related diseases
13:30-14:00: Robert Walczak (Genfit, Lille, France)
"The development of Elafibranor for the treatment of NASH, and NIS4 an IVD to identify NASH patients for treatment and track disease evolution"
14:00-14:30: Mathias Heikenwälder (Univ. Heidelberg, Germany)
“On the role of innate and adaptive immune cells in NASH and liver cancer development”
14:30-15:00: Gavin Richardson (Univ. Newcastle, UK)
“Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction”
15:00: concluding remarks by Benoit Deprez